Cargando…
Protein-intrinsic properties and context-dependent effects regulate pioneer-factor binding and function
Chromatin is a barrier to the binding of many transcription factors. By contrast, pioneer factors access nucleosomal targets and promote chromatin opening. Despite binding to target motifs in closed chromatin, many pioneer factors display cell-type specific binding and activity. The mechanisms gover...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103944/ https://www.ncbi.nlm.nih.gov/pubmed/37066406 http://dx.doi.org/10.1101/2023.03.18.533281 |