Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

An increasing number of mutations associated with devastating human diseases are diagnosed by whole-genome/exon sequencing. Recurrent de novo missense mutations have been discovered in B56δ (encoded by PPP2R5D), a regulatory subunit of protein phosphatase 2A (PP2A), that cause intellectual disabilit...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Cheng-Guo, Balakrishnan, Vijaya K., Parihar, Pankaj S., Konovolov, Kirill, Chen, Yu-Chia, Merrill, Ronald A, Wei, Hui, Carragher, Bridget, Sundaresan, Ramya, Cui, Qiang, Wadzinski, Brian E., Swingle, Mark R., Musiyenko, Alla, Honkanen, Richard, Chung, Wendy K., Suzuki, Aussie, Strack, Stefan, Huang, Xuhui, Xing, Yongna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103954/
https://www.ncbi.nlm.nih.gov/pubmed/37066309
http://dx.doi.org/10.1101/2023.03.09.530109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103954/
https://www.ncbi.nlm.nih.gov/pubmed/37066309
http://dx.doi.org/10.1101/2023.03.09.530109

Ejemplares similares