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High-throughput colocalization pipeline quantifies efficacy of mitochondrial targeting signals across different protein types

Efficient metabolic engineering and the development of mitochondrial therapeutics often rely upon the specific and strong import of foreign proteins into mitochondria. Fusing a protein to a mitochondria-bound signal peptide is a common method to localize proteins to mitochondria, but this strategy i...

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Detalles Bibliográficos
Autores principales: Lear, Sierra K., Nunez, Jose A., Shipman, Seth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103990/
https://www.ncbi.nlm.nih.gov/pubmed/37066162
http://dx.doi.org/10.1101/2023.04.03.535288