Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5’ untranslated region

One of the hallmarks of RNA viruses is highly structured untranslated regions (UTRs) in their genomes. These conserved RNA structures are often essential for viral replication, transcription, or translation. In this report, we discovered and optimized a new type of coumarin derivatives, such as C30...

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Detalles Bibliográficos
Autores principales: Tang, Zhichao, Hegde, Shalakha, Hao, Siyuan, Selvaraju, Manikandan, Qiu, Jianming, Wang, Jingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103992/
https://www.ncbi.nlm.nih.gov/pubmed/37066172
http://dx.doi.org/10.1101/2023.04.03.535453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103992/
https://www.ncbi.nlm.nih.gov/pubmed/37066172
http://dx.doi.org/10.1101/2023.04.03.535453

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