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Histone Deacetylases (HDACs) maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and non-coding loci
Histone acetylation is a dynamic modification regulated by the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Deacetylation of histone tails results in chromatin tightening and therefore HDACs are generally regarded as transcriptional repressors. Counterintui...
Autores principales: | RDW, Kelly, KR, Stengel, A, Chandru, LC4, Johnson, SW, Hiebert, SM, Cowley |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104071/ https://www.ncbi.nlm.nih.gov/pubmed/37066171 http://dx.doi.org/10.1101/2023.04.06.535398 |
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