Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa

Retinitis pigmentosa is an inherited photoreceptor degeneration that begins with rod loss followed by cone loss and eventual blindness. Gene therapies are being developed, but it is unknown how retinal function depends on the time of intervention. To uncover this dependence, we utilized a mouse mode...

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Detalles Bibliográficos
Autores principales: Scalabrino, Miranda L., Thapa, Mishek, Wang, Tian, Sampath, Alapakkam P., Chen, Jeannie, Field, Greg D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104154/
https://www.ncbi.nlm.nih.gov/pubmed/37066264
http://dx.doi.org/10.1101/2023.04.07.536035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104154/
https://www.ncbi.nlm.nih.gov/pubmed/37066264
http://dx.doi.org/10.1101/2023.04.07.536035

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