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Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance
Protein space is a rich analogy for genotype-phenotype maps, where amino acid sequence is organized into a high-dimensional space that highlights the connectivity between protein variants. It is a useful abstraction for understanding the process of evolution, and for efforts to engineer proteins tow...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104174/ https://www.ncbi.nlm.nih.gov/pubmed/37066177 http://dx.doi.org/10.1101/2023.04.09.535490 |