Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation

Immunomodulatory drugs (IMiDs), which include thalidomide and its derivatives, have emerged as the standard of care against multiple myeloma. They function as molecular glues that bind to the E3 ligase cereblon (CRBN) and induce protein interactions with neosubstrates, including the transcription fa...

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Detalles Bibliográficos
Autores principales: Arp, Christopher J., Reynders, Martin, Sreekanth, Vedagopuram, Kokkonda, Praveen, Pagano, Michele, Choudhary, Amit, Trauner, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104231/
https://www.ncbi.nlm.nih.gov/pubmed/37066279
http://dx.doi.org/10.1101/2023.04.09.536172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104231/
https://www.ncbi.nlm.nih.gov/pubmed/37066279
http://dx.doi.org/10.1101/2023.04.09.536172

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