Haploinsufficiency of ZNF251 causes DNA-PKcs-dependent resistance to PARP inhibitors in BRCA1-mutated cancer cells

Poly (ADP-ribose) polymerase (PARP) inhibitors represent a promising new class of agents that have demonstrated efficacy in treating various cancers, particularly those that carry BRCA1/2 mutations. The cancer associated BRCA1/2 mutations disrupt DNA double strand break (DSB) repair by homologous re...

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Detalles Bibliográficos
Autores principales: Li, Huan, Chatla, Srinivas, Liu, Xiaolei, Vekariya, Umeshkumar, Kim, Dongwook, Walt, Matthew, Lian, Zhaorui, Morton, George, Feng, Zijie, Yang, Dan, Liu, Hongjun, Reed, Katherine, Childers, Wayne, Yu, Xiang, Madzo, Jozef, Chitrala, Kumaraswamy Naidu, Skorski, Tomasz, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104263/
https://www.ncbi.nlm.nih.gov/pubmed/37066268
http://dx.doi.org/10.21203/rs.3.rs-2688694/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104263/
https://www.ncbi.nlm.nih.gov/pubmed/37066268
http://dx.doi.org/10.21203/rs.3.rs-2688694/v1

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