Characterization of altered molecular mechanisms in Parkinson’s disease through cell type–resolved multiomics analyses

Parkinson’s disease (PD) is a progressive neurodegenerative disorder. However, cell type–dependent transcriptional regulatory programs responsible for PD pathogenesis remain elusive. Here, we establish transcriptomic and epigenomic landscapes of the substantia nigra by profiling 113,207 nuclei obtai...

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Detalles Bibliográficos
Autores principales: Lee, Andrew J., Kim, Changyoun, Park, Seongwan, Joo, Jaegeon, Choi, Baekgyu, Yang, Dongchan, Jun, Kyoungho, Eom, Junghyun, Lee, Seung-Jae, Chung, Sun Ju, Rissman, Robert A., Chung, Jongkyeong, Masliah, Eliezer, Jung, Inkyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104466/
https://www.ncbi.nlm.nih.gov/pubmed/37058563
http://dx.doi.org/10.1126/sciadv.abo2467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104466/
https://www.ncbi.nlm.nih.gov/pubmed/37058563
http://dx.doi.org/10.1126/sciadv.abo2467

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