Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

Recent studies have described a DNA damage tolerance pathway choice that involves a competition between PrimPol-mediated repriming and fork reversal. Screening different translesion DNA synthesis (TLS) polymerases by the use of tools for their depletion, we identified a unique role of Pol ι in regul...

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Detalles Bibliográficos
Autores principales: Mansilla, Sabrina F., Bertolin, Agostina P., Venerus Arbilla, Sofía, Castaño, Bryan A., Jahjah, Tiya, Singh, Jenny K., Siri, Sebastián O., Castro, María Victoria, de la Vega, María Belén, Quinet, Annabel, Wiesmüller, Lisa, Gottifredi, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
https://www.ncbi.nlm.nih.gov/pubmed/37058556
http://dx.doi.org/10.1126/sciadv.ade7997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
https://www.ncbi.nlm.nih.gov/pubmed/37058556
http://dx.doi.org/10.1126/sciadv.ade7997

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