Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria

The alarming rise in superbugs that are resistant to drugs of last resort, including vancomycin-resistant enterococci and staphylococci, has become a significant global health hazard. Here, we report the click chemistry synthesis of an unprecedented class of shapeshifting vancomycin dimers (SVDs) th...

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Detalles Bibliográficos
Autores principales: Ottonello, Alessandra, Wyllie, Jessica A., Yahiaoui, Oussama, Sun, Shoujun, Koelln, Rebecca A., Homer, Joshua A., Johnson, Robert M., Murray, Ewan, Williams, Paul, Bolla, Jani R., Robinson, Carol V., Fallon, Thomas, Soares da Costa, Tatiana P., Moses, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104512/
https://www.ncbi.nlm.nih.gov/pubmed/37011186
http://dx.doi.org/10.1073/pnas.2208737120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104512/
https://www.ncbi.nlm.nih.gov/pubmed/37011186
http://dx.doi.org/10.1073/pnas.2208737120

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