LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro

The gamma-interferon (IFNγ)-inducible guanylate-binding proteins (GBPs) promote host defense against gram-negative cytosolic bacteria in part through the induction of an inflammatory cell death pathway called pyroptosis. To activate pyroptosis, GBPs facilitate sensing of the gram-negative bacterial...

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Detalles Bibliográficos
Autores principales: Dickinson, Mary S., Kutsch, Miriam, Sistemich, Linda, Hernandez, Dulcemaria, Piro, Anthony S., Needham, David, Lesser, Cammie F., Herrmann, Christian, Coers, Jörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104521/
https://www.ncbi.nlm.nih.gov/pubmed/37023136
http://dx.doi.org/10.1073/pnas.2216028120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104521/
https://www.ncbi.nlm.nih.gov/pubmed/37023136
http://dx.doi.org/10.1073/pnas.2216028120

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