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Steric pressure between glycosylated transmembrane proteins inhibits internalization by endocytosis

Clathrin-mediated endocytosis is essential for the removal of transmembrane proteins from the plasma membrane in all eukaryotic cells. Many transmembrane proteins are glycosylated. These proteins collectively comprise the glycocalyx, a sugar-rich layer at the cell surface, which is responsible for i...

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Detalles Bibliográficos
Autores principales: Gollapudi, Sadhana, Jamal, Sabah, Kamatar, Advika, Yuan, Feng, Wang, Liping, Lafer, Eileen M., Belardi, Brian, Stachowiak, Jeanne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104535/
https://www.ncbi.nlm.nih.gov/pubmed/37023126
http://dx.doi.org/10.1073/pnas.2215815120