Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion

Prions are proteinaceous infectious particles that replicate by structural conversion of the host-encoded cellular prion protein (PrP(C)), causing fatal neurodegenerative diseases in mammals. Species-specific amino acid substitutions (AAS) arising from single nucleotide polymorphisms within the prio...

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Detalles Bibliográficos
Autores principales: Arifin, Maria I., Kaczmarczyk, Lech, Zeng, Doris, Hannaoui, Samia, Lee, Chi, Chang, Sheng Chun, Mitchell, Gordon, McKenzie, Debbie, Beekes, Michael, Jackson, Walker, Gilch, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104538/
https://www.ncbi.nlm.nih.gov/pubmed/37014866
http://dx.doi.org/10.1073/pnas.2221060120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104538/
https://www.ncbi.nlm.nih.gov/pubmed/37014866
http://dx.doi.org/10.1073/pnas.2221060120

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