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STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice

Stimulator of interferon genes (STING) is a key mediator of type-I interferon (IFN-I) signaling in response to a variety of stimuli, but the contribution of STING to homeostatic processes is not fully characterized. Previous studies showed that ligand activation of STING limits osteoclast differenti...

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Detalles Bibliográficos
Autores principales: MacLauchlan, Susan, Kushwaha, Priyanka, Tai, Albert, Chen, Jia, Manning, Catherine, Swarnkar, Gaurav, Abu-Amer, Yousef, Fitzgerald, Katherine A., Sharma, Shruti, Gravallese, Ellen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104545/
https://www.ncbi.nlm.nih.gov/pubmed/37023130
http://dx.doi.org/10.1073/pnas.2210409120