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Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction

Controlling the selectivity of a reaction is critical for target-oriented synthesis. Accessing complementary selectivity profiles enables divergent synthetic strategies, but is challenging to achieve in biocatalytic reactions given enzymes’ innate preferences of a single selectivity. Thus, it is cri...

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Detalles Bibliográficos
Autores principales:	Chiang, Chang-Hwa, Wymore, Troy, Rodríguez Benítez, Attabey, Hussain, Azam, Smith, Janet L., Brooks, Charles L., Narayan, Alison R. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104550/ https://www.ncbi.nlm.nih.gov/pubmed/37014851 http://dx.doi.org/10.1073/pnas.2218248120

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