Surface patches induce nonspecific binding and phase separation of antibodies

Nonspecific interactions are a key challenge in the successful development of therapeutic antibodies. The tendency for nonspecific binding of antibodies is often difficult to reduce by rational design, and instead, it is necessary to rely on comprehensive screening campaigns. To address this issue,...

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Detalles Bibliográficos
Autores principales: Ausserwöger, Hannes, Krainer, Georg, Welsh, Timothy J., Thorsteinson, Nels, de Csilléry, Ella, Sneideris, Tomas, Schneider, Matthias M., Egebjerg, Thomas, Invernizzi, Gaetano, Herling, Therese W., Lorenzen, Nikolai, Knowles, Tuomas P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104583/
https://www.ncbi.nlm.nih.gov/pubmed/37011217
http://dx.doi.org/10.1073/pnas.2210332120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104583/
https://www.ncbi.nlm.nih.gov/pubmed/37011217
http://dx.doi.org/10.1073/pnas.2210332120

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