Interferon-β modulates microglial polarization to ameliorate delayed tPA-exacerbated brain injury in ischemic stroke

Tissue plasminogen activator (tPA) is the only FDA-approved drug for the treatment of ischemic stroke. Delayed tPA administration is associated with increased risks of blood-brain barrier (BBB) disruption and hemorrhagic transformation. Studies have shown that interferon beta (IFNβ) or type I IFN re...

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Detalles Bibliográficos
Autores principales: Kuo, Ping-Chang, Weng, Wen-Tsan, Scofield, Barbara A., Paraiso, Hallel C., Bojrab, Paul, Kimes, Brandon, Yu, I-Chen Ivorine, Yen, Jui-Hung Jimmy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104603/
https://www.ncbi.nlm.nih.gov/pubmed/37063896
http://dx.doi.org/10.3389/fimmu.2023.1148069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104603/
https://www.ncbi.nlm.nih.gov/pubmed/37063896
http://dx.doi.org/10.3389/fimmu.2023.1148069

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