Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)

T Cell homeostasis The article number 2206344 by Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu, and co‐workers uncovers that peripheral T cells can undergo necroptosis instead of apoptosis when endogenous RPA1 is deleted, which leads to severe lymphopenia and increases the susceptibility of autoinfl...

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Autores principales: Song, Jia, Zhang, Xin, Yin, Yue, Guo, Mengfan, Zhao, Xuyang, Wang, Likun, Ren, Caixia, Yin, Yuxin, Zhang, Xuehui, Deng, Xuliang, Lu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104623/
http://dx.doi.org/10.1002/advs.202370061
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author Song, Jia
Zhang, Xin
Yin, Yue
Guo, Mengfan
Zhao, Xuyang
Wang, Likun
Ren, Caixia
Yin, Yuxin
Zhang, Xuehui
Deng, Xuliang
Lu, Dan
author_facet Song, Jia
Zhang, Xin
Yin, Yue
Guo, Mengfan
Zhao, Xuyang
Wang, Likun
Ren, Caixia
Yin, Yuxin
Zhang, Xuehui
Deng, Xuliang
Lu, Dan
author_sort Song, Jia
collection PubMed
description T Cell homeostasis The article number 2206344 by Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu, and co‐workers uncovers that peripheral T cells can undergo necroptosis instead of apoptosis when endogenous RPA1 is deleted, which leads to severe lymphopenia and increases the susceptibility of autoinflammatory diseases. Accordingly, chemical or genetic inhibition of necroptosis signaling can ameliorate the inflammatory damage by Rpa1 deficiency and restore host immune homeostasis. [Image: see text]
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spelling pubmed-101046232023-04-15 Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023) Song, Jia Zhang, Xin Yin, Yue Guo, Mengfan Zhao, Xuyang Wang, Likun Ren, Caixia Yin, Yuxin Zhang, Xuehui Deng, Xuliang Lu, Dan Adv Sci (Weinh) Cover Picture T Cell homeostasis The article number 2206344 by Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu, and co‐workers uncovers that peripheral T cells can undergo necroptosis instead of apoptosis when endogenous RPA1 is deleted, which leads to severe lymphopenia and increases the susceptibility of autoinflammatory diseases. Accordingly, chemical or genetic inhibition of necroptosis signaling can ameliorate the inflammatory damage by Rpa1 deficiency and restore host immune homeostasis. [Image: see text] John Wiley and Sons Inc. 2023-04-14 /pmc/articles/PMC10104623/ http://dx.doi.org/10.1002/advs.202370061 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cover Picture
Song, Jia
Zhang, Xin
Yin, Yue
Guo, Mengfan
Zhao, Xuyang
Wang, Likun
Ren, Caixia
Yin, Yuxin
Zhang, Xuehui
Deng, Xuliang
Lu, Dan
Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)
title Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)
title_full Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)
title_fullStr Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)
title_full_unstemmed Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)
title_short Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)
title_sort loss of rpa1 impairs peripheral t cell homeostasis and exacerbates inflammatory damage through triggering t cell necroptosis (adv. sci. 11/2023)
topic Cover Picture
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104623/
http://dx.doi.org/10.1002/advs.202370061
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