SUMOylation inhibition enhances multiple myeloma sensitivity to lenalidomide

Despite the potent effect of lenalidomide (Len) in multiple myeloma (MM) treatment, patients develop Len resistance leading to progressive disease, demanding an urgent need to investigate the mechanisms mediating Len resistance. Our study identified SUMOylation as a potential mechanism regulating Le...

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Detalles Bibliográficos
Autores principales: Du, Li, Liu, Wei, Pichiorri, Flavia, Rosen, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104776/
https://www.ncbi.nlm.nih.gov/pubmed/35338347
http://dx.doi.org/10.1038/s41417-022-00450-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104776/
https://www.ncbi.nlm.nih.gov/pubmed/35338347
http://dx.doi.org/10.1038/s41417-022-00450-9

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