Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization

Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale three-dimensional genome reorganization following DNA damage and analyze the contribution of the nuclear WASP-ARP2/3-actin pat...

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Detalles Bibliográficos
Autores principales: Zagelbaum, Jennifer, Schooley, Allana, Zhao, Junfei, Schrank, Benjamin R., Callen, Elsa, Zha, Shan, Gottesman, Max E., Nussenzweig, André, Rabadan, Raul, Dekker, Job, Gautier, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104780/
https://www.ncbi.nlm.nih.gov/pubmed/36564591
http://dx.doi.org/10.1038/s41594-022-00893-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104780/
https://www.ncbi.nlm.nih.gov/pubmed/36564591
http://dx.doi.org/10.1038/s41594-022-00893-6

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