SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 was reported to alter several cellular pathways, its impact on DNA integrity and the mechanisms involved remain unknown. Here we show th...

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Detalles Bibliográficos
Autores principales: Gioia, Ubaldo, Tavella, Sara, Martínez-Orellana, Pamela, Cicio, Giada, Colliva, Andrea, Ceccon, Marta, Cabrini, Matteo, Henriques, Ana C., Fumagalli, Valeria, Paldino, Alessia, Presot, Ettore, Rajasekharan, Sreejith, Iacomino, Nicola, Pisati, Federica, Matti, Valentina, Sepe, Sara, Conte, Matilde I., Barozzi, Sara, Lavagnino, Zeno, Carletti, Tea, Volpe, Maria Concetta, Cavalcante, Paola, Iannacone, Matteo, Rampazzo, Chiara, Bussani, Rossana, Tripodo, Claudio, Zacchigna, Serena, Marcello, Alessandro, d’Adda di Fagagna, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104783/
https://www.ncbi.nlm.nih.gov/pubmed/36894671
http://dx.doi.org/10.1038/s41556-023-01096-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104783/
https://www.ncbi.nlm.nih.gov/pubmed/36894671
http://dx.doi.org/10.1038/s41556-023-01096-x

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