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Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2(B) and RAP1
Double-strand breaks (DSBs) due to genotoxic stress represent potential threats to genome stability. Dysfunctional telomeres are recognized as DSBs and are repaired by distinct DNA repair mechanisms. RAP1 and TRF2 are telomere binding proteins essential to protect telomeres from engaging in homology...
Autores principales: | Rai, Rekha, Biju, Kevin, Sun, Wenqi, Sodeinde, Tori, Al-Hiyasat, Amer, Morgan, Jaida, Ye, Xianwen, Li, Xueqing, Chen, Yong, Chang, Sandy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104862/ https://www.ncbi.nlm.nih.gov/pubmed/37059728 http://dx.doi.org/10.1038/s41467-023-37761-w |
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