Intercellular hif1α reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions

The origin of breast cancer, whether primary or recurrent, is unknown. Here, we show that invasive breast cancer cells exposed to hypoxia release small extracellular vesicles (sEVs) that disrupt the differentiation of normal mammary epithelia, expand stem and luminal progenitor cells, and induce aty...

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Detalles Bibliográficos
Autores principales: Bertolini, Irene, Perego, Michela, Nefedova, Yulia, Lin, Cindy, Milcarek, Andrew, Vogel, Peter, Ghosh, Jagadish C., Kossenkov, Andrew V., Altieri, Dario C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104898/
https://www.ncbi.nlm.nih.gov/pubmed/36892943
http://dx.doi.org/10.1172/JCI164348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104898/
https://www.ncbi.nlm.nih.gov/pubmed/36892943
http://dx.doi.org/10.1172/JCI164348

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