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Intercellular hif1α reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions
The origin of breast cancer, whether primary or recurrent, is unknown. Here, we show that invasive breast cancer cells exposed to hypoxia release small extracellular vesicles (sEVs) that disrupt the differentiation of normal mammary epithelia, expand stem and luminal progenitor cells, and induce aty...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104898/ https://www.ncbi.nlm.nih.gov/pubmed/36892943 http://dx.doi.org/10.1172/JCI164348 |