Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysi...

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Detalles Bibliográficos
Autores principales: Farr, Joshua N., Saul, Dominik, Doolittle, Madison L., Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Froemming, Mitchell N., Lagnado, Anthony B., Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J., Niedernhofer, Laura J., Robbins, Paul D., Jurk, Diana, Passos, João F., LeBrasseur, Nathan K., Tchkonia, Tamara, Kirkland, James L., Monroe, David G., Khosla, Sundeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104901/
https://www.ncbi.nlm.nih.gov/pubmed/36809340
http://dx.doi.org/10.1172/JCI162519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104901/
https://www.ncbi.nlm.nih.gov/pubmed/36809340
http://dx.doi.org/10.1172/JCI162519

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