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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysi...
Autores principales: | Farr, Joshua N., Saul, Dominik, Doolittle, Madison L., Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Froemming, Mitchell N., Lagnado, Anthony B., Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J., Niedernhofer, Laura J., Robbins, Paul D., Jurk, Diana, Passos, João F., LeBrasseur, Nathan K., Tchkonia, Tamara, Kirkland, James L., Monroe, David G., Khosla, Sundeep |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104901/ https://www.ncbi.nlm.nih.gov/pubmed/36809340 http://dx.doi.org/10.1172/JCI162519 |
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