Investigating The Correction of IVS II-1 (G> A) Mutation in HBB Gene in TLS-12 Cell Line Using CRISPR/Cas9 System

OBJECTIVE: Beta-thalassemia is a group of inherited hematologic. The most HBB gene variant among Iranian beta-thalassemia patients is related to two mutations of IVSII-1 (G>A) and IVSI-5 (G>C). Therefore, our aim of this study is to use the knock in capability of CRISPR Cas9 system to investig...

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Detalles Bibliográficos
Autores principales: Servatian, Nazli, Abroun, Saeid, Shahzadeh Fazeli, Seyed Abolhassan, Soleimani, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105294/
https://www.ncbi.nlm.nih.gov/pubmed/37038697
http://dx.doi.org/10.22074/CELLJ.2022.560725.1118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105294/
https://www.ncbi.nlm.nih.gov/pubmed/37038697
http://dx.doi.org/10.22074/CELLJ.2022.560725.1118

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