Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

The high morbidity and mortality associated with SARS-CoV-2 infection, the etiological agent of COVID-19, has had a major impact on global public health. Significant progress has been made in the development of an array of vaccines and biologics, however, the emergence of SARS-CoV-2 variants and bre...

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Detalles Bibliográficos
Autores principales: Dampalla, Chamandi S., Miller, Matthew J., Kim, Yunjeong, Zabiegala, Alexandria, Nguyen, Harry Nhat, Madden, Trent K., Thurman, Hayden A., Machen, Alexandra J., Cooper, Anne, Liu, Lijun, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105399/
https://www.ncbi.nlm.nih.gov/pubmed/37080108
http://dx.doi.org/10.1016/j.ejmech.2023.115376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105399/
https://www.ncbi.nlm.nih.gov/pubmed/37080108
http://dx.doi.org/10.1016/j.ejmech.2023.115376

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