To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining

Chromosomal DNA double-strand breaks (DSBs) are the effective lesion of radiotherapy and other clastogenic cancer therapeutics, and are also the initiating event of many approaches to gene editing. Ligation of the DSBs by end joining (EJ) pathways can restore the broken chromosome, but the repair ju...

Descripción completa

Detalles Bibliográficos
Autores principales: Cisneros-Aguirre, Metztli, Ping, Xiaoli, Stark, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105512/
https://www.ncbi.nlm.nih.gov/pubmed/35926296
http://dx.doi.org/10.1016/j.dnarep.2022.103380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105512/
https://www.ncbi.nlm.nih.gov/pubmed/35926296
http://dx.doi.org/10.1016/j.dnarep.2022.103380

Ejemplares similares