Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates

TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away. Despite their importance, the ubiquitination mechanism of TRIM ligases has remained elusive. Here...

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Detalles Bibliográficos
Autores principales: Kiss, Leo, Rhinesmith, Tyler, Luptak, Jakub, Dickson, Claire F., Weidenhausen, Jonas, Smyly, Shannon, Yang, Ji-Chun, Maslen, Sarah L., Sinning, Irmgard, Neuhaus, David, Clift, Dean, James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105713/
https://www.ncbi.nlm.nih.gov/pubmed/37061529
http://dx.doi.org/10.1038/s41467-023-37504-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105713/
https://www.ncbi.nlm.nih.gov/pubmed/37061529
http://dx.doi.org/10.1038/s41467-023-37504-x

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