Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF) recruits gp130:LIF receptor (LIFR) heterodimers...

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Detalles Bibliográficos
Autores principales: Rafii, Puyan, Seibel, Christiane, Weitz, Hendrik T., Ettich, Julia, Minafra, Anna Rita, Petzsch, Patrick, Lang, Alexander, Floss, Doreen M., Behnke, Kristina, Köhrer, Karl, Moll, Jens M., Scheller, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105715/
https://www.ncbi.nlm.nih.gov/pubmed/37061565
http://dx.doi.org/10.1038/s42003-023-04768-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105715/
https://www.ncbi.nlm.nih.gov/pubmed/37061565
http://dx.doi.org/10.1038/s42003-023-04768-4

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