Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice

The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity in a sex dependent manner. Clozapine N-oxide-i...

Descripción completa

Detalles Bibliográficos
Autores principales: Madar, Jonathan, Tiwari, Namrata, Smith, Cristina, Sharma, Divya, Shen, Shanwei, Elmahdi, Alsiddig, Qiao, Liya Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105732/
https://www.ncbi.nlm.nih.gov/pubmed/37061508
http://dx.doi.org/10.1038/s41467-023-37683-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105732/
https://www.ncbi.nlm.nih.gov/pubmed/37061508
http://dx.doi.org/10.1038/s41467-023-37683-7

Ejemplares similares