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Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice

The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity in a sex dependent manner. Clozapine N-oxide-i...

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Detalles Bibliográficos
Autores principales:	Madar, Jonathan, Tiwari, Namrata, Smith, Cristina, Sharma, Divya, Shen, Shanwei, Elmahdi, Alsiddig, Qiao, Liya Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105732/ https://www.ncbi.nlm.nih.gov/pubmed/37061508 http://dx.doi.org/10.1038/s41467-023-37683-7

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