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Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice
The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity in a sex dependent manner. Clozapine N-oxide-i...
Autores principales: | Madar, Jonathan, Tiwari, Namrata, Smith, Cristina, Sharma, Divya, Shen, Shanwei, Elmahdi, Alsiddig, Qiao, Liya Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105732/ https://www.ncbi.nlm.nih.gov/pubmed/37061508 http://dx.doi.org/10.1038/s41467-023-37683-7 |
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