Does AlphaFold2 model proteins’ intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins

A major goal in structural biology is to understand protein assemblies in their biologically relevant states. Here, we investigate whether AlphaFold2 structure predictions match native protein conformations. We chemically cross-linked proteins in situ within intact Tetrahymena thermophila cilia and...

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Detalles Bibliográficos
Autores principales: McCafferty, Caitlyn L., Pennington, Erin L., Papoulas, Ophelia, Taylor, David W., Marcotte, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105775/
https://www.ncbi.nlm.nih.gov/pubmed/37061613
http://dx.doi.org/10.1038/s42003-023-04773-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105775/
https://www.ncbi.nlm.nih.gov/pubmed/37061613
http://dx.doi.org/10.1038/s42003-023-04773-7

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