Characterization of the endotheliopathy, innate-immune activation and hemostatic imbalance underlying CAR-T cell toxicities: laboratory tools for an early and differential diagnosis

BACKGROUND: Chimeric antigen receptor (CAR)-T cell-based immunotherapy constitutes a revolutionary advance for treatment of relapsed/refractory hematological malignancies. Nevertheless, cytokine release and immune effector cell-associated neurotoxicity syndromes are life-threatening toxicities in wh...

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Detalles Bibliográficos
Autores principales: Moreno-Castaño, Ana Belen, Fernández, Sara, Ventosa, Helena, Palomo, Marta, Martinez-Sanchez, Julia, Ramos, Alex, Ortiz-Maldonado, Valentín, Delgado, Julio, Fernández de Larrea, Carlos, Urbano-Ispizua, Alvaro, Penack, Olaf, Nicolás, J M, Téllez, Adrian, Escolar, Gines, Carreras, Enric, Fernández-Avilés, Francesc, Castro, Pedro, Diaz-Ricart, Maribel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106034/
https://www.ncbi.nlm.nih.gov/pubmed/37045474
http://dx.doi.org/10.1136/jitc-2022-006365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106034/
https://www.ncbi.nlm.nih.gov/pubmed/37045474
http://dx.doi.org/10.1136/jitc-2022-006365

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