Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca(2+)-dependent gap junction intercellular communication

BACKGROUND: Imatinib mesylate (IM) resistance is an emerging problem for chronic myeloid leukemia (CML). Previous studies found that connexin 43 (Cx43) deficiency in the hematopoietic microenvironment (HM) protects minimal residual disease (MRD), but the mechanism remains unknown. METHODS: Immunohis...

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Detalles Bibliográficos
Autores principales: Li, Xiaoping, Xiao, Yunshuo, Wang, Xiaoqi, Huang, Ruihao, Wang, Rui, Deng, Yi, Rao, Jun, Gao, Qiangguo, Yang, Shijie, Zhang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106204/
https://www.ncbi.nlm.nih.gov/pubmed/36801891
http://dx.doi.org/10.1097/CM9.0000000000002554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106204/
https://www.ncbi.nlm.nih.gov/pubmed/36801891
http://dx.doi.org/10.1097/CM9.0000000000002554

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