Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases

Inactivation of tetracycline antibiotics by tetracycline destructases (TDases) remains a clinical and agricultural threat. TDases can be classified as type 1 Tet(X)-like TDases and type 2 soil-derived TDases. Type 1 TDases are widely identified in clinical pathogens. A combination therapy of tetracy...

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Detalles Bibliográficos
Autores principales: Kumar, Hirdesh, Williford, Emily E., Blake, Kevin S., Virgin-Downey, Brett, Dantas, Gautam, Wencewicz, Timothy A., Tolia, Niraj H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106456/
https://www.ncbi.nlm.nih.gov/pubmed/37062778
http://dx.doi.org/10.1038/s42003-023-04792-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106456/
https://www.ncbi.nlm.nih.gov/pubmed/37062778
http://dx.doi.org/10.1038/s42003-023-04792-4

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