Synthetic oleanane triterpenoids suppress MYB oncogene activity and sensitize T-cell acute lymphoblastic leukemia cells to chemotherapy

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with poor prognosis. The MYB oncogene encodes a master transcription factor that is activated in the majority of human T-ALLs. In the present study, we have performed a large-scale screening with small-molecule drugs...

Descripción completa

Detalles Bibliográficos
Autores principales: Tejera Nevado, Paloma, Tešan Tomić, Tajana, Atefyekta, Ali, Fehr, André, Stenman, Göran, Andersson, Mattias K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106619/
https://www.ncbi.nlm.nih.gov/pubmed/37077825
http://dx.doi.org/10.3389/fonc.2023.1126354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106619/
https://www.ncbi.nlm.nih.gov/pubmed/37077825
http://dx.doi.org/10.3389/fonc.2023.1126354

Ejemplares similares