Reshaping the 2‐Pyrone Synthase Active Site for Chemoselective Biosynthesis of Polyketides

Engineering enzymes with novel reactivity and applying them in metabolic pathways to produce valuable products are quite challenging due to the intrinsic complexity of metabolic networks and the need for high in vivo catalytic efficiency. Triacetic acid lactone (TAL), naturally generated by 2‐pyrone...

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Detalles Bibliográficos
Autores principales: Zhou, Yu, Mirts, Evan N., Yook, Sangdo, Waugh, Matthew, Martini, Rachel, Jin, Yong‐Su, Lu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107152/
https://www.ncbi.nlm.nih.gov/pubmed/36398563
http://dx.doi.org/10.1002/anie.202212440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107152/
https://www.ncbi.nlm.nih.gov/pubmed/36398563
http://dx.doi.org/10.1002/anie.202212440

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