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Reshaping the 2‐Pyrone Synthase Active Site for Chemoselective Biosynthesis of Polyketides
Engineering enzymes with novel reactivity and applying them in metabolic pathways to produce valuable products are quite challenging due to the intrinsic complexity of metabolic networks and the need for high in vivo catalytic efficiency. Triacetic acid lactone (TAL), naturally generated by 2‐pyrone...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107152/ https://www.ncbi.nlm.nih.gov/pubmed/36398563 http://dx.doi.org/10.1002/anie.202212440 |