Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering

Over recent decades, the pipeline of antibiotics acting against Gram‐negative bacteria is running dry, as most discovered candidate antibiotics suffer from insufficient potency, pharmacokinetic properties, or toxicity. The darobactins, a promising new small peptide class of drug candidates, bind to...

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Detalles Bibliográficos
Autores principales: Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107326/
https://www.ncbi.nlm.nih.gov/pubmed/36308277
http://dx.doi.org/10.1002/anie.202214094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107326/
https://www.ncbi.nlm.nih.gov/pubmed/36308277
http://dx.doi.org/10.1002/anie.202214094

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