Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data

Quantitative relationships between carcinogenic potency and mutagenic potency have been previously examined using a benchmark dose (BMD)‐based approach. We extended those analyses by using human exposure data for 48 compounds to calculate carcinogenicity‐derived and genotoxicity‐derived margin of ex...

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Detalles Bibliográficos
Autores principales: Chepelev, Nikolai, Long, Alexandra S., Beal, Marc, Barton‐Maclaren, Tara, Johnson, George, Dearfield, Kerry L., Roberts, Daniel J., van Benthem, Jan, White, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107494/
https://www.ncbi.nlm.nih.gov/pubmed/36345771
http://dx.doi.org/10.1002/em.22517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107494/
https://www.ncbi.nlm.nih.gov/pubmed/36345771
http://dx.doi.org/10.1002/em.22517

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