AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

AP2S1 is the sigma 2 subunit of adaptor protein 2 (AP2) that is essential for endocytosis. In this study, we investigated the potential role of AP2S1 in intracellular processing of amyloid precursor protein (APP), which contributes to the pathogenesis of Alzheimer disease (AD) by generating the toxi...

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Detalles Bibliográficos
Autores principales: Wen, Qi‐Xin, Luo, Biao, Xie, Xiao‐Yong, Zhou, Gui‐Feng, Chen, Jian, Song, Li, Liu, Yue, Xie, Shi‐Qi, Chen, Long, Li, Kun‐Yi, Xiang, Xiao‐Jiao, Chen, Guo‐Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107530/
https://www.ncbi.nlm.nih.gov/pubmed/36412210
http://dx.doi.org/10.1111/tra.12874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107530/
https://www.ncbi.nlm.nih.gov/pubmed/36412210
http://dx.doi.org/10.1111/tra.12874

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