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From passage to inhibition: Uncovering the structural and physiological inhibitory mechanisms of MCUb in mitochondrial calcium regulation

Mitochondrial calcium (Ca(2+)) regulation is critically implicated in the regulation of bioenergetics and cell fate. Ca(2+), a universal signaling ion, passively diffuses into the mitochondrial intermembrane space (IMS) through voltage‐dependent anion channels (VDAC), where uptake into the matrix is...

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Detalles Bibliográficos
Autores principales: Colussi, Danielle M., Stathopulos, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107711/
https://www.ncbi.nlm.nih.gov/pubmed/36538269
http://dx.doi.org/10.1096/fj.202201080R