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Readily Accessible Strained Difunctionalized trans‐Cyclooctenes with Fast Click and Release Capabilities
The click reaction between a functionalized trans‐cyclooctene (TCO) and a tetrazine (Tz) is a compelling method for bioorthogonal conjugation in combination with payload releasing capabilities. However, the synthesis of difunctionalized TCOs remains challenging. As a result, these compounds are poor...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107714/ https://www.ncbi.nlm.nih.gov/pubmed/36478614 http://dx.doi.org/10.1002/chem.202203375 |