Cargando…

Tonic extracellular glutamate and ischaemia: glutamate antiporter system x(c) (−) regulates anoxic depolarization in hippocampus

ABSTRACT: In stroke, the sudden deprivation of oxygen to neurons triggers a profuse release of glutamate that induces anoxic depolarization (AD) and leads to rapid cell death. Importantly, the latency of the glutamate‐driven AD event largely dictates subsequent tissue damage. Although the contributi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heit, Bradley S., Chu, Alex, Sane, Abhay, Featherstone, David E., Park, Thomas J., Larson, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107724/ https://www.ncbi.nlm.nih.gov/pubmed/36321247 http://dx.doi.org/10.1113/JP283880

Ejemplares similares

Symport and antiport mechanisms of human glutamate transporters
por: Qiu, Biao, et al.
Publicado: (2023)

Distribution of Extracellular Glutamate in the Neuropil of Hippocampus
por: Herman, Melissa A., et al.
Publicado: (2011)

Increased expression of cystine/glutamate antiporter in multiple sclerosis
por: Pampliega, Olatz, et al.
Publicado: (2011)

The cystine/glutamate antiporter system x(c)(−) drives breast tumor cell glutamate release and cancer-induced bone pain
por: Slosky, Lauren M., et al.
Publicado: (2016)

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
por: Shin, Chun-Shik, et al.
Publicado: (2017)

Cystine/glutamate antiporter System x(c)(-) deficiency impairs insulin secretion in mice
por: de Baat, Axel, et al.
Publicado: (2023)

α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release
por: Lazarevic, Vesna, et al.
Publicado: (2022)

Change of cystine/glutamate antiporter expression in ethanol-dependent rats
por: Peana, Alessandra T., et al.
Publicado: (2014)

Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues
por: Martis, Renita M., et al.
Publicado: (2020)

Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
por: Fournier, M., et al.
Publicado: (2017)

Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury
por: Meyer, Anne R., et al.
Publicado: (2019)

The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer
por: Jyotsana, Nidhi, et al.
Publicado: (2022)

High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells
por: Thomas, Ajit G., et al.
Publicado: (2015)

Modulation of Extracellular Proton Fluxes from Retinal Horizontal Cells of the Catfish by Depolarization and Glutamate
por: Kreitzer, Matthew A., et al.
Publicado: (2007)

The System xc- Cystine/Glutamate Antiporter: An Exciting Target for Antiepileptogenic Therapy?
por: Gallagher, Martin
Publicado: (2020)

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
por: Arensman, Michael D., et al.
Publicado: (2019)

Cystine/Glutamate antiporter system x(c)(-) deficiency impairs macrophage glutathione metabolism and cytokine production
por: de Baat, Axel, et al.
Publicado: (2023)

Depolarization time and extracellular glutamate levels aggravate ultraearly brain injury after subarachnoid hemorrhage
por: Murai, Satoshi, et al.
Publicado: (2022)

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter
por: Bentea, Eduard, et al.
Publicado: (2020)

Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment
por: Hung, Chung-Chieh, et al.
Publicado: (2021)

Molecular basis for redox control by the human cystine/glutamate antiporter system xc(−)
por: Parker, Joanne L., et al.
Publicado: (2021)

Early Onset of Age-Related Cataracts in Cystine/Glutamate Antiporter Knockout Mice
por: Martis, Renita Maria, et al.
Publicado: (2021)

The x(c)(−) cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance
por: Lo, M, et al.
Publicado: (2008)

Astroglial Glutamate Signaling and Uptake in the Hippocampus
por: Rose, Christine R., et al.
Publicado: (2018)

Immunotherapy against the Cystine/Glutamate Antiporter xCT Improves the Efficacy of APR-246 in Preclinical Breast Cancer Models
por: Barutello, Giuseppina, et al.
Publicado: (2022)

Anoxic spreading depolarization in the neonatal rat cortex in vitro
por: Gainutdinov, Azat, et al.
Publicado: (2023)

Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization
por: Andrew, R. David, et al.
Publicado: (2022)

The Cystine/Glutamate Antiporter, System x(c)(–), Contributes to Cortical Infarction After Moderate but Not Severe Focal Cerebral Ischemia in Mice
por: He, Yan, et al.
Publicado: (2022)

Structural investigation of human cystine/glutamate antiporter system x(c) (−) (Sx(c) (−)) using homology modeling and molecular dynamics
por: Hang, Tran Dieu, et al.
Publicado: (2022)

The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells
por: Madry, Christian, et al.
Publicado: (2010)

The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization
por: Hübel, Niklas, et al.
Publicado: (2017)

Yokukansan, a Kampo Medicine, Protects PC12 Cells from Glutamate-Induced Death by Augmenting Gene Expression of Cystine/Glutamate Antiporter System Xc(−)
por: Kanno, Hitomi, et al.
Publicado: (2014)

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
por: Lim, Jonathan K. M., et al.
Publicado: (2019)

Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models
por: Ruiu, Roberto, et al.
Publicado: (2023)

Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission
por: Fukuyama, Kouji, et al.
Publicado: (2018)

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis
por: Ashraf, Azhaar, et al.
Publicado: (2020)

Effect of hypocapnia on extracellular glutamate and glycine concentrations during peri-ischemic period in the rabbit hippocampus.
por: Choi, K. T., et al.
Publicado: (1994)

The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization
por: Ullah, Ghanim, et al.
Publicado: (2015)

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
por: Vallerga, Costanza L., et al.
Publicado: (2020)

Genes involved in Drosophila glutamate receptor expression and localization
por: Liebl, Faith LW, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_8sg9ln6t8dj0i0ojlutrragob9