Decreased Water Mobility Contributes To Increased α‐Synuclein Aggregation

The solvation shell is essential for the folding and function of proteins, but how it contributes to protein misfolding and aggregation has still to be elucidated. We show that the mobility of solvation shell H(2)O molecules influences the aggregation rate of the amyloid protein α‐synuclein (αSyn),...

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Detalles Bibliográficos
Autores principales: Stephens, Amberley D., Kölbel, Johanna, Moons, Rani, Chung, Chyi Wei, Ruggiero, Michael T., Mahmoudi, Najet, Shmool, Talia A., McCoy, Thomas M., Nietlispach, Daniel, Routh, Alexander F., Sobott, Frank, Zeitler, J. Axel, Kaminski Schierle, Gabriele S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107867/
https://www.ncbi.nlm.nih.gov/pubmed/36316279
http://dx.doi.org/10.1002/anie.202212063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107867/
https://www.ncbi.nlm.nih.gov/pubmed/36316279
http://dx.doi.org/10.1002/anie.202212063

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