Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR(7) Allosteric Agonist

[Image: see text] The low affinity metabotropic glutamate receptor mGluR(7) has been implicated in numerous CNS disorders; however, a paucity of potent and selective activators has hampered full delineation of the functional role and therapeutic potential of this receptor. In this work, we present t...

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Detalles Bibliográficos
Autores principales: Dickson, Louise, Teall, Martin, Chevalier, Elodie, Cheung, Toni, Liwicki, Gemma M., Mack, Stephen, Stephenson, Anne, White, Kathryn, Fosbeary, Richard, Harrison, David C., Brice, Nicola L., Doyle, Kevin, Ciccocioppo, Roberto, Wu, Chaobo, Almond, Sarah, Patel, Toshal R., Mitchell, Philip, Barnes, Matt, Ayscough, Andrew P., Dawson, Lee A., Carlton, Mark, Bürli, Roland W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107911/
https://www.ncbi.nlm.nih.gov/pubmed/37077399
http://dx.doi.org/10.1021/acsmedchemlett.2c00529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107911/
https://www.ncbi.nlm.nih.gov/pubmed/37077399
http://dx.doi.org/10.1021/acsmedchemlett.2c00529

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